Adherence to Antiretroviral Therapy for Pediatric HIV Infection: A Qualitative Systematic Review With Recommendations for Research and Clinical Management
Identifieur interne : 000647 ( Main/Exploration ); précédent : 000646; suivant : 000648Adherence to Antiretroviral Therapy for Pediatric HIV Infection: A Qualitative Systematic Review With Recommendations for Research and Clinical Management
Auteurs : Jane M. Simoni [États-Unis] ; Arianna Montgomery [Géorgie (pays)] ; Erin Martin [États-Unis] ; Michelle New [États-Unis] ; Penelope A. Demas [États-Unis] ; Sohail Rana [États-Unis]Source :
- Pediatrics [ 0031-4005 ] ; 2007.
Abstract
Although nonadherence to prescribed therapies is widespread, it is particularly problematic with highly active antiretroviral therapy for HIV infection. This review of >50 studies in the area of pediatric HIV infection revealed varying methods for assessing antiretroviral adherence with a wide range of estimates of adherence. Correlates of adherence could be grouped as those relating to the medication, the patient, and the caregiver/family, with many conflicting findings and a lack of theory guiding the research. Only 8 studies, mainly small feasibility or pilot investigations, evaluated highly active antiretroviral therapy adherence interventions in pediatric populations. We conclude with specific recommendations for assessment and clinical management of adherence and discuss directions for future research in this area.
Url:
DOI: 10.1542/peds.2006-1232
PubMed: 17533177
PubMed Central: 5096441
Affiliations:
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Demas</name><affiliation wicri:level="2"><nlm:aff id="A5">AIDS Research Program, Montefiore Medical Center, Bronx, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>AIDS Research Program, Montefiore Medical Center, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Rana, Sohail" sort="Rana, Sohail" uniqKey="Rana S" first="Sohail" last="Rana">Sohail Rana</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Pediatrics and Child Health, Howard University, Washington, DC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>Department of Pediatrics and Child Health, Howard University, Washington</wicri:cityArea></affiliation></author></analytic><series><title level="j">Pediatrics</title><idno type="ISSN">0031-4005</idno><idno type="eISSN">1098-4275</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Although nonadherence to prescribed therapies is widespread, it is particularly problematic with highly active antiretroviral therapy for HIV infection. 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